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KMID : 0370219960400060621
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Yakhak Hoeji
1996 Volume.40 No. 6 p.621 ~ p.624
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Synthesis of Phenolbetaine Derivatives Introduction of Functional Groups to C-ring and Chemical Transformation of BC-ring of Protoberberine
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우성주/Woo SJ
황순호/박예진/홍유화/이마세/김인종/김신규/Hwang SH/Park YJ/Hong YH/Lee MS/Kim IJ/Kim SK
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Abstract
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Betaine was treated with hydrochloric acid and then with sodium borohydride to give a hydroxy compound 2. The reaction of 2 with thionyl chloride followed by thiourea led a compound 5. Oxidation of compound 2 with pyridinium dichromate(PDC) and succesive treatment with Lawesson’’s reagent also afforded the same compound 5. Cleavage of N-C14 bond compound of 7 was carried out via two reaction sequence from the compound 4. Finally, compound 10 was sythesized by a series of transformations from the compound 4.
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KEYWORD
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